When I moved here just about the only people (outside of work) that I knew were part of a group called Skeptics in the Pub. It is hard to sum up what the group is in a few lines, but it is a place inquisitive people can chat about issues as diverse as alternative medicine, ghosts, religion or psychics... although we usually end up talking about technology, beer, TV shows and beer. It is mostly, but not exclusively, made up of people who would describe themselves as atheist, agnostic, rational, or humanist.
I have met some really great people there this year, we had our first talk (Stevyn Colgan on Luck), our local MP came along, the journalist Martin Robbins is an occasional visitor, and the usual crowd are always up for a drink, beer festival or night out at short notice, which was really good when I didn't know anyone else in town!
I has been designated an assistant organiser, and although I have no idea what this entails I am trying to get a bit organised for next year, some more talks (a few big names have promised to help us out!) and hope to expand numbers a bit. I am looking forward to it, but we need a suitable venue for the events, which is proving the really hard bit! So if anyone has a small hall in Wycombe they are willing to hire cheaply...
More about Skeptics in the pub at the Wikidedia page.
More about our group here.